Annual Review of Immunology Volume 25 2007 - download pdf or read online

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N. R. R. M. A. Dwek, manuscript submitted). New ways of synthesizing oligomannose glycans and clustering them on scaffolds using linkers are also being designed. Figure 8 Model of the domain-swapped Fabs of the IgG 2G12 antibody complexed with the oligomannose cluster (green) on the silent face of HIV gp120 (turquoise). Model adapted from Reference 11. The IgG LCs are purple, and the γ-chains are blue and red. The VH regions are exchanged in this unique domain-swapped structure and form an extended paratope that can accommodate the D1 arms of three oligomannose sugars.

For personal use only. Fc receptors (FcRs) link the cellular and humoral immune responses. The stimulation of cells expressing these receptors by the Fc regions of Igs has dramatic consequences, including antibody-dependent cellmediated cytotoxicity (ADCC), phagocytosis, oxidative burst, and release of inflammatory mediators. IgG Fc Glycans Are Required for Optimal Fcγ Receptor Binding Fcγ receptors are expressed on leukocytes, including macrophages, eosinophils, neutrophils, natural killer cells, and lymphocytes, and there are three distinct classes: FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16) (87).

25:21-50. org by HINARI on 08/26/07. For personal use only. ANRV306-IY25-02 ARI 13 February 2007 18:12 (Table 1). Surprisingly, low levels of the monoglucosylated oligomannose structures, Glc1 Man9 GlcNAc2 and Glc1 Man8 GlcNAc2 , have been detected at Asn-354 (31, 58). Glc1 Man9 GlcNAc2 binds to calnexin and calreticulin in the ER (59, 60), acting as a retention signal to ensure the correct folding and assembly of glycoproteins (61, 62). The glucose residue is normally removed by the ER glucosidase II when the protein is fully folded.

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