By Q. Alan Xu, Timothy L. Madden
This e-book is a compilation of summarized analytical equipment designed to serve the wishes of pharmacologists, toxicologists, and different allied future health execs concerned the improvement, use, or tracking of prescription drugs. The summaries are based monographs on 511 various drug entities detailing 964 diverse analytical equipment, supplying the reader with an intensive description of strategy validation. those analytical tools contain not just excessive functionality liquid chromatography (HPLC), but additionally gasoline chromatography (GC), immunoassay, electrophoresis, extremely functionality liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With extra exact and whole summaries than sketchy and abbreviated codecs utilized in the opposite books, this booklet offers an intensive description of strategy validation and effects, in addition to the working parameters.
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Extra resources for Analytical Methods for Therapeutic Drug Monitoring and Toxicology
A Merck–Hitachi HPLC system consisting of a model AS4000 autosampler, model D6000 interface, model L6200 intelligent pump, model T6300 column thermostat, and model L4250 UV–visible detector was used. The stationary phase was a Spherisorb 5CN column (250 × 4 mm). The mobile phase consisted of 46% acetonitrile and 54% of an aqueous solution containing 60 mM sodium sulfate and 5 mM sulfuric acid and was isocratically delivered at 1 mL/min. UV detection was performed at 294 nm. 4 mg/mL was prepared in deionized water.
The temperature of autosamper was maintained at 4◦ C. An ABI-SCIEX API3000 triple quadrupole tandem mass spectrometer with TurboIonSpray source was coupled to the liquid chromatograph as a detector. It was operated in positive ionization mode. 5 kV, source temperature at 450◦ C, collisionactivated dissociation at 12, and the collision gas nitrogen. The declustering potential was 38 V and collision energy 95 V. 2 for amiodarone, sulfisomedine, sulfamethoxydiazine, and sulfadimethoxine, respectively.
Reagent 1 (R1) and Reagent 2 (R2) were separately dissolved with 6 mL of distilled water, and EMIT drug assay buffer concentrate was diluted with distilled water (1 : 14, vol/vol). One part of R1 and R2 was then separately mixed with 8 parts of EMIT drug assay buffer. The optical density changes were monitored for a shorter period of time than recommended by the manufacturer. A linear calibration curve was constructed over the range from 1 to 50 g/mL. 0%, respectively. Results by the Dimension RxL Max EMIT were compared with those by the Abbott TDx FLx FPIA using linear regression analysis and Bland–Altaman plots to assess bias.
Analytical Methods for Therapeutic Drug Monitoring and Toxicology by Q. Alan Xu, Timothy L. Madden