By George Stouffer
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Additional resources for Adverse Drug Interactions - A Handbook for Prescribers
As important is the induction and inhibition of metabolizing enzymes. See the section below on cytochrome enzymes for more details. • Excretion may be altered by the induction or inhibition of transport proteins, and by decreases in blood flow to the organs where excretion takes place (liver and kidney). • First-pass metabolism. All drugs absorbed from the gastrointestinal tract (the exception being drugs administered per rectum) pass through the liver, where a portion of the drug is metabolized before reaching the systemic circulation.
Ciclosporin, digoxin, ergotamine, phenytoin, pimozide, quinidine, tacrolimus, terfenadine, theophylline), there is only a small difference between the level that produces the desired clinical effect and the concentration that results in undesired, adverse or toxic effects. Consequently, drugs with a narrow therapeutic index are more likely to be associated with clinically significant drug–drug interactions, because even small changes in concentration are likely to have significant clinical effects.
Anaesthetic drugs Anaesthetics – general 10. Drugs to treat infections Other antibiotics prazosin prednisolone prilocaine promethazine propafenone propanolol pseudoephedrine see sympathomimetics 138 pyrazinamide xlviii 557 Subcategory (drug groups only) Antimuscarinics Progestogens Antimuscarinics INDEX OF DRUG NAMES Drug (primary) Page Part of the Book Category Subcategory (drug groups only) pyridostigmine 283, 284 2. Drugs acting on the nervous system Neuromuscular and movement disorders Parasympathomimetics pyrimethamine 588–589 10.
Adverse Drug Interactions - A Handbook for Prescribers by George Stouffer