By Esen Özkaya, Kurtuluş Didem Yazganoğlu
Adverse cutaneous drug reactions (ACDR) are one of the so much widespread occasions in sufferers receiving drug remedy. Cardiovascular (CV) medicinal drugs are a massive workforce of substances with capability probability of constructing ACDR in particular in aged as advertising and marketing of extra new medicines and their prescription proceed to extend. in spite of the fact that, like with such a lot different medicinal drugs the precise prevalence of cutaneous negative effects from CV medicines is tough to estimate because of sporadic reporting. additionally, a competent designation of a definite drug because the reason behind a undeniable form of response can not often be made. except the well known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid response from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV medicines will be obvious in a large spectrum extending to infrequent yet life-threatening stipulations similar to erythroderma, Stevens-Johnson syndrome, poisonous epidermal necrolysis or drug allergy syndrome. during this finished assessment, the stated varieties of ACDR to CV medicines might be mentioned in keeping with drug classification and the kind of dermatologic response with certain emphasize on cross-reactions and the function of patch trying out in diagnosis.
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Additional resources for Adverse Cutaneous Drug Reactions to Cardiovascular Drugs
It may be idiopathic or related with several systemic diseases or drug therapies . Oral contraceptives and sulfonamides are common inducers. Drug-Induced Erythroderma/Exfoliative Dermatitis Erythroderma/exfoliative dermatitis is characterized by widespread confluent erythema that is often associated with desquamation, involving more than 80 % of the body surface (Figs. 57). It is a condition with a significant risk of morbidity and mortality. , maculopapular, lichenoid, eczematous, may evolve into erythroderma during their course.
Cutaneous eruption may be variable such as palpable purpura with/without hemorrhagic vesicles, urticarial lesions, or EM-like lesions in SSLR. Leukocytoclastic vasculitis is usually seen in the histopathology of cutaneous lesions. Urticarial lesions seen in drug-induced SSLR commonly represent urticarial vasculitis. Unlike the true serum sickness, a type III hypersensitivity reaction, however, vasculitis and fever are not consistent findings in the reported cases of SSLR. Besides, gastrointestinal disturbances, lymphadenopathy, low complement levels, circulating immune complexes, and proteinuria associated with renal involvement are usually absent or rarely reported in drug-induced SSLR [4, 73].
62 Symmetrical erythemato-squamous plaques on the malar areas and above the upper lip in a patient with subacute cutaneous lupus erythematosus-like eruption possibly induced by filgrastim, a granulocyte colony-stimulating factor 42 1 General Aspects of Adverse Cutaneous Drug Reactions Fig. 63 Erythematosquamous plaques on the back and symmetrically on the upper extremities, mainly in annular–polycyclic configuration, in a patient with subacute cutaneous lupus erythematosus-like eruption possibly induced by filgrastim, a granulocyte colony-stimulating factor Fig.
Adverse Cutaneous Drug Reactions to Cardiovascular Drugs by Esen Özkaya, Kurtuluş Didem Yazganoğlu