New PDF release: Advances in Immunology, Vol. 38

By Frank J. Dlxon (Ed.)

ISBN-10: 0120224380

ISBN-13: 9780120224388

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Extra resources for Advances in Immunology, Vol. 38

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81, 161. Hannum, C. , Kappler, J. , Trowbridge, 1. S . , and Freed, J. H. (1984b). Nature (London) 312, 65. , and Appella, E. (1983). J . E x p . Med. 158, 25. , and Marrack, P. J. Exp. Med. 157, 1149. Hayday, A. , Gilles, S . , Kranz, D. , Eisen, H. , and Tonegawa, S . (1985). Cell 40 (in press). , Schwartz, R. , Matis, L. , and Hansburg, D. J . E x p . Med. 155, 1086. , Morgan, R . , Hecht, B. , and Smith, S. D. (1984). Science 226, 1445. , and Davis, M. (1984a). Nature (London) 308, 149. Hedrick, S .

Haskins, K. , and Kappler, J. (1983). J . Irnmunol. 130, 1033. , and Marrack, P. (1985). Submitted. , and Mak, T. (1984). Nature (London) 30, 145. , and Unanue, E. R. (1979). J . Exp. Med. 150, 1143. Zinkernagel, R. , and Doherty, P. C. (1975). J . E x p . Med. 141, 1427. Zinkernagel, R. , and Doherty, P. C. (1977). Contemp. Top. Znzmunobiol. 7, 179. , and Klein, J. J . Erp. Med. 147, 882. ADVANCES IN IMMUNOLOGY, VOL. 38 immune Response (Ir) Genes of the Murine Major Histocompatibility Complex RONALD H.

First, T cells which bind free antigen would not be efficiently triggered, because stimulation of virgin T cells requires not only interaction with their receptors, but also accessory cell-derived lymphokines such as interleukin-1, thus only T cells which bind antigen on accessory cells are triggered in a primary response. Moreover, T cells which bind free antigen would also be useless at the effector cell level, since T cells are designed to interact with other cells. Last, T cells should not bind so effectively to their targets that they cannot release them and move on to act on another target cell.

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Advances in Immunology, Vol. 38 by Frank J. Dlxon (Ed.)


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