By Paul Cheremisinoff
This addition to the Advances in Environmental keep watch over expertise sequence comprises 23 chapters designed to supply an in depth review and reference on human physiological responses to numerous types of toxins.
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Additional info for Advances in Environmental Control Technology: Health and Toxicology (Advances in Environmental Control Technology)
Epithelial cell linings from fetal lung tissue of golden hamsters and also from human trachea and bronchi are recommended for testing chemical toxicity. This material is useful for establishing more accurate correlations between in vitro and in vivo data. Present in the cell membranes, sulphydryl groups have high affinity for mercury and its compounds. Cell membranes, therefore, are the first site of damage by Hg and other heavy metals. Exposure to Hg compounds may raise the concentration of metalothioneine-like protein in kidneys.
During early stages of poisoning with organic mercury, the highest concentration of this metal was found in the kidney, and at later stages in the liver and brain. Four to six weeks after the affliction, mercury content decreased significantly in the kidney and liver, although it still remained high in the brain. Introduced by Harada, neurological tests are, therefore, useful for detection of early symptoms of Minamata disease, associated also with increased risk of neoplastic changes of some blood cells.
The course of neoplastic disease depends on the reaction of the organism to the formation and development of the neoplasm as an individual biological system capable of existence, and further growth only if it remains in a state far from the internal equilibrium of the body. Accordingly, the suppression of such a state alone is sufficient to achieve a cure. The sooner the removal from the body of the neoplasm as the source supporting the state far from the equilibrium of its environment by means of taking up and dissipating matter and energy, the faster and easier the cure.
Advances in Environmental Control Technology: Health and Toxicology (Advances in Environmental Control Technology) by Paul Cheremisinoff