By J. Lemerle, M. F. Tournade, C. Patte (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)
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Study week of the Pontificial Academy of Sciences, Vatican City, Oct. 17-21, 1977 (in press) 44 H. Strander et al. 2. , Mogensen, K. : Human leukocyte interferon: Production, purification, stability and animal experiments. In: The production and use of interferon for the treatment and prevention of human virus infection (in vitro). Waymouth, M. C. ), pp. 35-38. Culture Association Workshop. Rockville: Tissue Culture Association 1974 3. : Human leukocyte interferon for clinical use. In: Blood leukocytes function and use in therapy.
2. In comparison to the control, 5-formyl-tetrahydrofolate (= citrovorum factor = CF) alone has no significant effect either on the cell growth or on the incorporation rates of 3H-dTR and 3H-dUR. Under normal conditions, the incorporation rates for these two nucleosides are nearly equal. 3. 4t M CHO-FHt. Control 1500 500 e-e_e_. ,. ,. Incorp. 3H- dURIncorp. 100 1 234 1 2 3 4 1 234 1234 Days Fig. 2. DNA metabolism in cultured human lymphoblasts (LS 2). Effects of methotrexate (MTX) and citrovorum factor (leucovorin = CHO-FH 4) from the biochemical mechanism, the dUR incorporation falls almost to zero after MTX whereas the dTR incorporation increases considerably.
9/11 , ----~ "~8/10 \ 75% \ \7/10 \ '~~~ ______ o3/5 Group B 50% \ .............. 214 4/9 \1/3 b Group A 25% Fig. 1. Disease-free interval of patients with osteosarcoma treated by adjuvant chemotherapy (direct curve) months 5 10 15 20 Randomized Trial of Adjuvant Chemotherapy in Osteogenic Osteosarcoma 31 Toxicity Protocol A was generally not as well tolerated by patients as protocol B because of a 2-day hospitalization for the high-dose methotrexate administration. One toxic death with severe aplasia and septicemia and severe mucosal toxicity was provoked by administration of highdose methotrexate.
Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II: Adjuvant Therapies of the Various Primary Tumors by J. Lemerle, M. F. Tournade, C. Patte (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)