Download e-book for kindle: Abeta Peptide and Alzheimer’s Disease: Celebrating a Century by David H. Small BSc, PhD (auth.), Colin J. Barrow BSc

By David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)

ISBN-10: 1846284406

ISBN-13: 9781846284403

ISBN-10: 1852339616

ISBN-13: 9781852339616

Abeta Peptide and Alzheimer’s illness summarizes present wisdom of beta-amyloid peptide (Aß) and its position because the significant offender in Alzheimer’s sickness (AD), proven by way of contemporary advances in genetics and mind biochemistry.

Written through leaders within the commercial and educational international focusing on this swiftly relocating quarter, the booklet covers primary biochemical stories at the Aß peptide, the genetic influence on Aß expression and processing, and diverse advert healing options that concentrate on Aß. even though in particular concentrating on Aß and advert, there's additionally a few dialogue at the similarity and modifications of this peptide and advert with different amyloidogenic ailments, similar to prion sickness, Parkinson’s and Huntington’s.

This publication will essentially be of curiosity to advert researchers and clinicians but in addition to researchers of alternative amyloid diseases.

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Extra info for Abeta Peptide and Alzheimer’s Disease: Celebrating a Century of Research

Example text

Amyloid beta protein gene:cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science, 1987. 235(4791):880-884. 56. , Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer’s disease and Down syndrome. Lancet, 1987. 1(8529):384-385. 57. , Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science, 1990. 248(4959):1120-1122. 58. , Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

74(1):270-279. 301. , Copper, beta-amyloid, and Alzheimer’s disease: tapping a sensitive connection. Proc Natl Acad Sci U S A, 2003. 100(20):11193-11194. 302. , Dramatic aggregation of Alzheimer Aß by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem, 1998. 273(21):1281712826. 303. , Copper catalyzed oxidation of Alzheimer Aß. Cell Mol Biol, 2000. 46(4):777-783. 304. , The Aß peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction.

244. , Toxicity of enzymically-oxidized low-density lipoprotein. Biochem Biophys Res Commun, 1987. 148(1):260-266. 245. G. , Oxidative stress and gene regulation. Free Radic Biol Med, 2000. 28(3): 463-499. 246. , Oxidative damage to DNA in mammalian chromatin. Mutat Res, 1992. 275(3-6): 331-342. 247. , Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol, 2000. 1(2):120-129. 248. , Characterization of 8-epiprostaglandin F2alpha as a marker of amyloid beta-peptide-induced oxidative damage.

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Abeta Peptide and Alzheimer’s Disease: Celebrating a Century of Research by David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)

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