New PDF release: A world-wide survey of new data and trends in adverse drug

By J.K. Aronson (Eds.)

ISBN-10: 0444505121

ISBN-13: 9780444505125

The uncomfortable side effects of substances Annual is designed to supply a serious and up to date account of recent details on the topic of adversarial drug reactions and interactions from the clinician's viewpoint. less than the supervision of the sequence editors, a global workforce of professional authors have accrued jointly the most recent details on hostile drug results from the foreign literature. as well as describing new studies of inauspicious drug results, the authors have subjected these reviews to serious research, surroundings them into context by way of scientific relevance and significance, and cross-referring to earlier experiences the place worthwhile. New opposed results are stated and evaluated and formerly said antagonistic results are re-evaluated within the mild of the latest details. a different characteristic is the studies, within which chosen opposed results are mentioned intensive. using the booklet is more desirable via separate indexes, permitting the reader to go into the textual content by means of drug identify, adversarial impact identify, or drug interplay. the present Annual is the 1st replace of the normal encyclopaedic paintings during this box, http://www.elsevier.nl/locate/isbn/0444500936Meyler's unwanted side effects of substances, Fourteenth version, which was once released in December 2000.

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Additional resources for A world-wide survey of new data and trends in adverse drug reactions

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Cocaethylene pharmacology, physiology and beha- ChapterI 9 vioral effects in humans. J Pharmacol Exp Ther 1995; 274: 215-23. 25. Bourland JA, Martin DK, Mayersohn M. Carboxyesterase transesterification of meperidine (Demerol) and methylphenidate (Ritalin | in the presence of [2H6] ethanol: preliminary in vitro findings using rat liver preparation. J Pharm Sci 1997; 86: 1494--6. 26. Schaller JL, Behar D. Carbamazepine and methylphenidate in ADHD. J Am Acad Child Adolesc Psychiatry 1999; 38:112-13.

Ann Pharmacother 1999; 33: 812-15. 64. Greene YM, Noviasky J, Tariot PN. Donepezil overdose. J Clin Psychiatry 1999; 60: 56-7. 65. Carder L. Donepezil and paroxetine: possible drug interaction. J Am Geriatr Soc 1999; 47: 1037. 66. Ringman JM, Cummings JL. Metrifonate (Trichlorfon): a review of the pharmacology, pharmacokinetics and clinical experience with a new acetylcholinesterase inhibitor for Alzheimer's disease. Expert Opin Invest Drugs 1999; 8: 463-74. 67. Dubois B, McKeith I, Orgogozo JM, Collins O, Meulien D, and MALT Study Group.

In 31 healthy male and female volunteers (mean age 28 years) the ability of four SSRIs (fluoxetine, fluvoxamine, paroxetine, and sertraline) to inhibit CYP2D6 activity was assessed in vivo, as judged by the dextromethorphan test (23c). All were extensive metabolizers of dextromethorphan. After 8 days treatment at therapeutic doses, four of eight paroxetine-treated and five of eight fluoxetine-treated subjects had become poor metabolizers, presumably because of the inhibitory effect of the two SSRIs on CYP2D6 activity.

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A world-wide survey of new data and trends in adverse drug reactions by J.K. Aronson (Eds.)


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